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Haematology: Beyond the Numbers

Presenter: Prof. Diane Brown

Webinar: “Haematology: Beyond the Numbers”

When: Monday, the 16th of October 2017 at 15:00-16:00 GMT + 1 (Dublin time)

Synopsis: To maximize the opportunity to detect phenotypes, disease, and responses to therapeutic interventions in animals, accurate haematologic studies and the morphologic assessment of peripheral blood, and including bone marrow and spleen (particularly for rodents) is additive to results obtained from automated haematology analyzers. The morphology of erythrocytes, leukocytes and platelets, and their precursors, can provide clues to pathogenesis in many diseases, and features identified by blood film and bone marrow review can add tremendously to the characterization of phenotypes. Results from automated haematology analyzers should always be verified by manual blood film review, especially when atypically high or low values are reported, and review of instrument-generated cell-population histograms provides useful details on these populations. Physiologic variables in some species may decrease the efficacy of automated analyses. Genetic mutations, iron deficiency, neoplasia and inflammatory disease are examples of disorders that can cause changes in cell morphology, maturation, numbers or size. Case examples will be utilized to demonstrate these features and characterization of haematologic responses beyond the numbers obtained by automated haematology analyzers in veterinary species.