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The Impact of the Microbiota on Animal Models

Presenter: Professor Axel Kornerup Hansen

Webinar Title: The Impact of the Microbiota on Animal Models

When: 29th of May, 15:00-16:00 GMT

Synopsis: The microbiota impacts disease expression in a range of animal models of e.g. inflammatory bowel disease (IBD), diabetes, obesity, psychiatric disease and dermatitis. Also single bacteria such as segmented filamentous bacteria (SFB), Akkermansia muciniphila, Prevotella spp. and Bifidobacteria. In the long run, we may be able to produce animals with less variation by microbiota standardization by inoculation of tailor made microbiotas, e.g. from human patients, or feeding certain prebiotic diets. To do so, we still need to solve some basic problems, but already today the laboratory animal veterinarian has a range of possibilities for reducing the destructive impact of the microbiota on animal studies. It is important to secure that factors such as stress, dietary fluctuations and unstandardized housing, which may change the microbiota of the animal, and thereby the animal model and cause uncontrolled variation, is reduced to an absolute minimum. A good service would be to characterize the microbiota of individual animals when used for microbiota sensitive studies to allow the scientist to incorporate this information in data evaluation, thereby turning this uncontrolled variation into controlled variation.