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Mouse Genetics

Rodent Genetics: The Basics

Presenter: Prof. Fernando Benavides

Webinar Title: Rodent Genetics: The Basics

When: 27th of March, 16:00-17:00 GMT

Synopsis: The mouse is the laboratory mammal whose genetics is best known, followed by the rat. The mouse is also the main species used in biomedical research with a constantly growing number of researchers using it as an animal model and for genome annotation. The essential aspects of rodent biology will be covered before presenting the basics of the genetics of the laboratory mouse, along with notes on the laboratory rat.

Genetically Defined Mouse and Rat Strains

Presenter: Prof. Fernando Benavides

Webinar Title: Genetically Defined Mouse and Rat Strains

When: 28th of June, 16:00-17:00 GMT

Synopsis: In this webinar the main characteristics and peculiarities of the different strains and stocks of laboratory mice and rats (from the genetic point of view) will be described. This will include the description of inbred, hybrid F1, congenic, recombinant inbred, and recombinant congenic strains, plus outbred stocks. In addition to details on how these strains are produced and maintained as well as their advantages and disadvantages in the context of animal experiments.

mportance of Genetic Background on Mice and Rat Models

Presenter: Prof. Fernando Benavides

Webinar Title: Importance of Genetic Background on Mice and Rat Models

When: 20th September, 16:00-17:00 GMT

Synopsis: It is increasingly recognized that the genetic background (i.e., all genomic sequences other than the gene(s) of interest) can have profound influences on the phenotype of an animal model. It has been shown that mutations (spontaneous and induced), transgenes, and targeted alleles (knockouts and knockins) that are “moved” onto a different background can show a change in phenotype. In order to highlight the importance of this issue, a selection of recently published articles showing the influence of genetic background on different mouse and rat models will be presented, along with different ways to avoid or resolve these problems. Finally a summary of differences within classical substrains of mice, including the so-called “passenger mutations” will be discussed.

Genetic Quality Control of Inbred Strains, 4th of December 2018

Presenter: Prof. Fernando Benavides

Webinar Title: Genetic Quality Control of Inbred Strains

When: 4th of December, 16:00-17:00 GMT

Synopsis: Genetic quality control, including genetic monitoring of inbred strains and background characterization of genetically altered mice and rats, should be an essential component of any quality assurance program in laboratory animal facilities. The availability of genetic markers needed for these controls is directly related with the presence of polymorphisms, and the techniques used to detect them have been historically shared with forensic DNA profiling. A historical perspective as well as the state of the art techniques and recommendations for the use of microsatellites and SNPs will be discussed.

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