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Systematic Reviews of Animal Experiments

Systematic Reviews of animal studies introduction.

Presenter: Dr. Judith van Luijk

Webinar Title: Systematic Reviews of animal studies introduction, comprehensive search, reporting, implementing 3Rs

When: 13th of August, 15:00-16:00 GMT

Synopsis: This webinar will focus on the basic concept of systematic reviews of animal studies. The value of comprehensive literature search and adequate reporting of animal studies will be demonstrated and discussed in relation to the systematic review methodology and 3R implementation. Helpful tips and tools will be provided to improve reporting and search skills in animal-based research.

Systematic Reviews in toxicology and evidence-based toxicology. 8th October 2018

Presenter: Prof. Katya Tsaioun

Webinar Title: Systematic Reviews in toxicology and evidence-based toxicology

When: 8th of October, 15:00-16:00 GMT

Synopsis: The difficulties in translating the evidence provided by science into
policy are well-documented. At the same time, the pressure on industries
and regulators to bring regulatory paradigms in all fields up to date with
scientific developments while making it transparent and objective is
mounting. In 2014 the US NRC addressed this impasse directly, by
recommending the use of Systematic Reviews (SR) pioneered by the Cochrane
Collaboration (CC) in medicine, for assessing evidence from toxicology for
regulatory policy. With their emphasis on transparency, objectivity, and
consistency, evidence-based approaches and their principal tool, the
systematic review (SR), have substantially improved clinical research
practices in medicine. They hold the same potential for toxicology, where
regulatory agencies (e.g., EFSA, US EPA, NIEHS OHAT) started to adopt and
adapt principles and tools of Evidence-Based Medicine (EBM) for hazard and
risk assessment of chemicals. The talk will cover the history, basic
principles and framework of EBM, followed by an example of the
implementation of SR in toxicological test methods comparison: a SR of the
Zebrafish Embryo Test for prenatal developmental toxicity and OECD
Guideline 414 mandated animal tests, with special focus on using of the
software and AI-based tools to overcome the difficulties of conducting
this work in the toxicology field.

Systematic Reviews in (bio)medical research and translation. 12th of November 2018

Presenter: Prof. Merel Ritskes-Hoitinga

Webinar Title: Systematic Reviews in (bio)medical research and translation

When: 12th of November, 15:00-16:00 GMT

Synopsis: In this webinar the value of systematic reviews in (bio)medical research will be highlighted and used to generate perspective on the decline in the success of drug development. The relationship to quality and translation of animal studies will be demonstrated and discussed. Cases from real life on (failing) translation from animal studies to human patients are dissected. Possible solutions aiming to improve the current situation on quality and translation will be provided.

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